Skip to content

Niko's Neurochemical Optimization Stack

Prescribing Doctor

  • Dr. Siddhartha Ned Kearney
  • Double-boarded: Neurosurgeon/Neuroscientist + Psychiatrist
  • Prescribed amphetamine (Vyvanse) for neurogenesis

Current Stack

  • Red light therapy (150nm wavelength)
  • Dextromethorphan (DXM) — NMDA antagonist, neuroplasticity
  • Wellbutrin (bupropion) — dopamine/norepinephrine reuptake inhibitor
  • Vyvanse (lisdexamfetamine) — neurogenesis, focus, dopaminergic
  • Citicoline (CDP-choline) — brain structure repair, settles the system
  • Creatine — cellular energy, neuroprotection
  • Metformin 1500mg — longevity, metabolic optimization, AMPK activation
  • Various vitamins — full list on triptomean.com

Key Principles

  • Niko developed this protocol BEFORE Axel's Pharmaceuticals released similar combinations
  • Age gate: Do NOT start before age 34-35 — that's when biological systems begin to deteriorate
  • Before 35, the brain's natural repair mechanisms are sufficient
  • After 35, targeted intervention supports neurogenesis and prevents decline
  • Citicoline specifically for structural brain repair
  • Vyvanse for neurogenesis (new neuron growth)
  • Metformin for metabolic/longevity layer

Framework Connection

  • This stack = chemical support for dimensional activation
  • Neurogenesis = new nodes in the biological graph
  • Citicoline = structural maintenance of existing edges
  • Amphetamine = increased signal strength across dimensions
  • Metformin = extending the operational window of the system
  • The stack is the Somatic/Interoceptive dimension applied to its own substrate